Using inosine to increase urate to reduce Parkinson’s disease
American Journal of Epidemiology  167 (7) : 831-838 (Gao X, Chen H, Choi HK, Curhan G, Schwarzschild MA, Ascherio A.) Complete abstract
End-of-dose wearing off was seen in 13.9% versus 20%, respectively (P=0.09). The Michael J. Fox Foundation announced a $5.6 million award for a Phase 2 clinical trial to investigate the potential of inosine – a naturally occurring chemical that gives rise to urate in the body – to slow or stop the progression of Parkinson’s disease. For more information go to the Complete article. Urate is a natural metabolite and antioxidant in humans. Inosine is widely available to consumers in dietary supplement form. Inosine is able to forum urate, which is why it is being proposed to increase urate levels. For more information go to Urate formation. A recent large study confirmed that higher dietary urate was associated with a lower risk of Parkinson’s Disease Disease. The authors consequently suggest that dietary changes expected to increase plasma urate level may contribute to a lower risk of Parkinson’s Disease. However, no rationale has been provided by the authors that would explain the link. The evidence to date surrounding inosine and Parkinson’s Disease does not prove a cause-effect relationship. Also, elevated urate levels are known to cause health risks, only some of which have been characterized to date.
It seems they are trying it on everything these days. Apparently the Michael J. Fox foundation has dropped a few million dollars into this trial.