So, my previous post got me wondering, do Alzheimer’s sufferers have lower uric acid levels than normal?
It seems a combination of uric acid and vitamin C are being suggested as a treatment.
Inhibition of Iron-Catalyzed Oxidations by Attainable Uric Acid and Ascorbic Acid Levels: Therapeutic Implications for Alzheimer’s Disease and Late Cognitive Impairment
William H. Waugh
Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, N.C., USA
Background: Alzheimer’s disease (AD) has become one of the major health problems of the developed world. Previous studies have shown that oxidant-induced changes occur in cerebral tissue in AD and in late-onset amnestic mild cognitive impairment. The oxidative damage begins early and involves free radical-mediated effects that cause lipid peroxidations and oxidative protein and nucleic acid damages which begin before the cardinal neuropathologic manifestations. Impaired cerebral iron homeostasis and iron accumulation are postulated to be primary and seminal in the pathogenesis. Objective: To demonstrate that the Fenton reaction involving hydrogen peroxide and iron at very low concentrations as has been found in human plasma and cerebrospinal fluid may produce promptly oxidations which may be inhibited by preventive use of uric acid and ascorbic acid as hydrophilic antioxidants. Methods: A photometric study in vitro at physiologic pH using concentrations of uric acid and ascorbic acid readily attainable in human extracellular fluids. Results: Uric acid levels of 0.5 and 6.0 mg/dl (below the saturation level for urate precipitation) and ascorbic acid at a level readily attainable in blood plasma inhibited significantly and completely, respectively, oxidations caused by reactions of 20 µM concentrations of hydrogen peroxide with free bivalent iron at 9.8 µM and at a low hemoglobin level of 12 mg/dl of saline.
Conclusion: Results suggest that supplemental use orally of ascorbic acid combined with use of metabolic precursor to uric acid, like inosine or hypoxanthine, has the potential for preventing or attenuating the progression of AD and amnestic mild cognitive impairment.
A little extra digging has turned up the fact that fructose boosts uric acid levels, so if you have Alzheimer’s or MS, swap over your sugar to fructose.